Your concentration-time profile, analysed in the browser — then reviewed, and turned into the regimen it supports
Paste a table of time and concentration — one subject or many, any mass unit, BLQ values as they came from the lab. The page computes the non-compartmental analysis at once: Cmax, AUC, the terminal phase and half-life, clearance and volume, with every acceptance criterion checked. The profile lane tells you which of those numbers you can report and why. The regimen lane takes the same profile, a dose and an interval, and predicts the steady state by superposition against your target window.
All three examples ship with a saved model run, so you can see the whole result — the NCA table, the chart, the reviewer's verdict, the steady-state prediction — without signing in and without spending a credit.
What this does, and what it does not
The page is a non-compartmental calculator, and it shows its working. AUC is the linear-up/log-down trapezoid; the terminal phase is the run of at least three points after Tmax with the best adjusted R² (Tmax included for an IV bolus, where the peak is the first sample); AUC to infinity adds Clast/λz and the page states what fraction that is. Clearance is dose over AUCinf — or over AUCτ when you say the profile is at steady state — and volume is clearance over λz. For extravascular dosing those are CL/F and Vz/F, because bioavailability is not in a single profile. BLQ values before the first measurable sample count as zero; embedded and trailing ones are excluded and flagged. Everything is computed in hours, mg/L and mg, whatever units you pasted, and the conversion is stated.
The model does what the arithmetic cannot: it reads the shape of the curve, grades each parameter as reliable, caution, unreliable or not estimable in the light of the acceptance criteria — at least three terminal points, adjusted R² of 0.8, no more than 20% of AUC extrapolated, a terminal span of two half-lives — answers every flag the page raised, and says whether the numbers are reportable. Its verdict follows a fixed rule the page re-derives, and every parameter value it cites is checked against the page's own number. The regimen lane predicts steady state by superposition of the observed curve — no compartmental model, no fitted parameters beyond λz — scaled to the proposed dose, and the model judges that prediction against your target window, names the assumptions, and says what to monitor.
Nothing here is medical advice, and no number leaves your browser until you press the button. Nothing to hand? Load the , the , or the . All three replay a saved run for free.